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Name:Pimaricin

Synonyms:Natamycin

Molecular Formula:C33H47NO13

Molecular Weight:665.73

CAS Registry Number:7681-93-8

EINECS:231-683-5

Natamycin has a very low solubility in water, due to the amphiphilic nature of the molecule. However, natamycin is effective at very low levels. Most Molds have an MIC (Minimum inhibitory concentration) of <10ppm. Natamycin is classified as a macrolide polyene antifungal and, as a drug, is used to treat fungal keratitis. It is especially effective against Aspergillus and Fusarium corneal infections. Other common members of the polyene macrolide antifungal family are Amphotericin B, Nystatin, and Filipin.

Uses

In foods

Natamycin has been used for decades in the food industry as a hurdle to fungal outgrowth in dairy products, meats, and other foods. Potential advantages for the usage of natamycin might include the replacement of traditional chemical preservatives, a neutral flavor impact, and less dependence on pH for efficacy, as is common with chemical preservatives. It may be applied by spraying a liquid suspension, by dipping the product in an aqueous suspension (known as a "brine"), or by mixing it into the product in a powdered form along with cellulose (a known "anti-caking" agent) on whole, shredded, or soft cheeses. While not currently approved for use on meats in the United States, some countries allow natamycin to be applied to the surface of dry and fermented sausages to prevent mold growth on the casing. Also, natamycin is approved for various dairy applications in the United States. More specifically, natamycin is commonly used in products such as cottage cheese, sour cream, and yogurt. As a food additive, it has E number E235.

Medical

Natamycin is used to treat fungal infections, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. It is applied as a cream, in eyedrops, or (for oral infections) in a lozenge. Natamycin shows negligible absorption into the body when administered in these ways. When taken orally, little or none is absorbed from the gastrointestinal tract, making it inappropriate for systemic infections.

Safety

Natamycin lacks acute toxicity. In animal studies, the lowest LD50 found was 450 mg/kg. In rats, the LD50 is ≥2300 mg/kg, and doses of 500 mg/kg/day over 2 years caused no detectable differences in survival rate, growth, or incidence of tumors. The metabolites of natamycin also lack toxicity. The breakdown products of natamycin under various storage conditions may have a lower LD50 than natamycin, but in all cases the numbers are quite high. In humans, a dose of 500 mg/kg/day repeated over multiple days caused nausea, vomiting, and diarrhea.

Specification
ITEM DESCRIPTION
Product Name Natamycin
Titer 50%
Carrier Dextrose
Standard Enterprise Standard
Strain Streptomyces natalensis
Description Almost white powder
EU NO.  E235
Synonyms Pimaricin   INS NO.235
Solubility 0.005 - 0.01 g100ml in aqueous
18.5g100m  in Glacial acetic acid
Stability PH 5 -- 7        No activity loss
PH 3 -- 5        10% activity loss
PH<3 or PH>9   30% activity loss.
Moisture 8% Max
Heavy Metals 0.002% Max
Protein & (other)Carbohydrate 2% Max
pH 5.0-7.5
Total colony count Not more than 100 CFU/g
Coliform group Not Detected
Salmonellae Not Detected

 

Packing:  100g/bottle; 500g/bottle; 10kg/drum

Storage: Natamycin is stable under room temperature. sunlight ,Oxidant, heavy metal will hurt the activity of Natamycin
Be laid in dry , shady and cool place(below 20)with sealed packing

Shelf life:2 years

 

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